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Author: Admin | 2025-04-28
Of cannabis. Combining the two substances increases the likelihood of experiencing panic attacks, anxiety attacks, and memory loss.⁴More research is needed to understand better the potentially harmful side effects of combining gabapentin and cannabis. How Does Gabapentin Interact with CBDTHC is the prominent cannabinoid responsible for the intoxicating experience that happens when you consume cannabis. CBD is another widely known cannabinoid that does not produce an intoxicating effect. While both have therapeutic benefits, CBD has become a more common introductory compound for those beginning to use cannabis for medicinal purposes. Seizures and epilepsy are among the most common conditions that CBD has been studied to treat. Just as the evidence is limited and conflicting for THC, the same goes for CBD. And, just as THC can be both therapeutic and cause unwanted negative effects, so can CBD. It has the potential to cause sleepiness if taken in higher doses.A 2020 study reviewed how CBD interacted with several different prescription medications. They reported that combining CBD with substances that can have sedative and anesthetic effects can result in both therapeutic as well as adverse effects.⁵ CBD has been studied for decades regarding its potential to reduce seizures in patients with epilepsy, both in clinical and less controlled settings.⁶ A study published in 1981 found that seven out of eight people using CBD to treat their epilepsy saw an improvement in the state of their condition.⁷ Many people with epilepsy also self-report treating their disease with CBD and often find success. While this is an excellent development, more controlled studies must be done to deeper understand how specifically CBD affects seizures and patients with epilepsy. It’s also vital to better understand how cannabinoids, like CBD, interact with the medications used to treat those conditions, like gabapentin. There is a potential concern that cannabinoids, like THC and CBD, may inhibit the metabolism of drugs through interactions with cytochrome P450 (CYP) enzymes. However, while most drugs metabolize via CYP enzymes, gabapentin does not. It isn’t metabolized to any degree in humans and is excreted intact in the urine. This may provide insight as to why gabapentin has shown few adverse effects when combined with cannabis in the limited published studies regarding the two.Conclusion Gabapentin is a prescription medication that can treat a variety of conditions, like epilepsy or restless leg syndrome. How it interacts in the body simultaneously with cannabis depends on factors that are currently unknown. Research is limited, especially in controlled human studies, regarding how the two substances interact with the nervous system and how they affect pain.Further research is needed, and current findings are conflicting. Self-reports claim that cannabis has helped reduce their intake of gabapentin, and gabapentin has been studied
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