Comment
Author: Admin | 2025-04-28
Indications/UsesPrednisone is indicated in a wide variety of clinical circumstances or disorders affecting the endocrine, nervous, cardiovascular, renal (e.g. nephrotic syndrome), gastrointestinal, skin and integumentary systems, ocular and respiratory system of inflammatory and allergic origin (e.g. bronchial asthma and skin allergies).Suspension: Prednisone is also useful in rheumatic, collagen, neoplastic, hematologic and autoimmune disorders such as autoimmune hemolytic anemia, idiopathic thrombocytopenic purpura, inflammatory bowel diseases, systemic lupus erythematosus and some cases of Hashimoto's thyroiditis.Dosage/Direction for UseDosage may vary depending on the severity of the disorder and the response of the patient.Prednisone is usually taken at 5-60 mg daily in divided doses or as a single dose after breakfast or as a double dose on alternate days. Some patients may temporarily require higher dose to control the disease. Dosage is reduced gradually or tapered off as soon as symptoms diminish. Or as prescribed by the physician.Tablet: As an immunosuppressive agent, the usual dose range for prednisone is 10-100 mg orally, daily.5-25 mg daily in divided doses may be given for primary and secondary adrenocortical insufficiency.10-20 mg/m2 body surface may be administered daily in divided doses in adrenogenital syndromes.OverdosageTablet: Prednisone overdose may include symptoms such as fever, muscle or joint pain, nausea, dizziness, fainting, difficulty of breathing. Prolonged overuse can manifest as moon face, obesity, unusual hair growth, acne, loss of sexual function and muscle wasting. Large doses of prednisone may produce Cushingoid symptoms typical of adrenal cortex hyperactivity.Adverse events should be treated symptomatically, with the prednisone dosage reduced or slowly withdrawn or tapered off whenever possible to prevent adrenal insufficiency.AdministrationShould be taken with food.ContraindicationsSystemic fungal infections, glaucoma, gastric and duodenal ulcers, certain viral infections, acute infections uncontrolled by antibiotic therapy and severe psycho-neuroses.Special PrecautionsHigh doses or chronic therapy with prednisone should be undertaken with great caution in patients with heart disease, hypertension, renal dysfunction, peptic ulcer, systemic fungal infection, history of psychotic disorders, diabetes mellitus, epilepsy, tuberculosis, osteoporosis, glaucoma, hypothyroidism, myasthenia gravis, hepatic failure, diverticulitis, colitis and viral diseases like herpes.Patients who receive high dose or those on long term therapy should also be monitored for the following adverse effects: hyperglycemia, glucosuria, sodium retention with edema, hypertension, osteoporosis and fungal infection.Treatment should not be abruptly stopped. Dosage should be reduced or slowly withdrawn or tapered off to prevent adrenal insufficiency. Treatment regimen should always be under medical supervision. Before therapy is initiated, cardiovascular function and psychologic status should be assessed.Use In Pregnancy
Add Comment