Dose of sugammadex

sugammadex, a repeat dose of 4 mg/kg sugammadex is recommended. Following a second dose of sugammadex, the patient should be closely monitored to ascertain

Rocuronium-sugammadex complex can also be displaced by fusidic acid or high doses of flucloxacillin. Drugs like magnesium, aminoglycosides potentiate muscle relaxants; to counteract these effects, a larger dose of sugammadex may be required.

Options for endotracheal intubation include succinylcholine, intubation without an NMBA (eg, high dose remifentanil intubation, although this technique is associated with more trauma), or rocuronium or vecuronium if sugammadex is available for rapid reversal of block. (See 'Sugammadex' below.)

Sugammadex rapidly clears from most organs. Sugammadex in doses ranging from 2 to 16 mg/kg is recommended, depending of the level of rocuronium- or vecuronium-

The dose of sugammadex required to achieve a train-of-four ratio of 0.9 or greater varied from 0.43 to 5.6 mg/kg. There was a statistically significant relationship between the depth of neuromuscular blockade and the sugammadex dose required for reversal, but there was a large variation in dose required at any depth of neuromuscular blockade.

by JR Renew Cited by 12rocuronium or vecuronium if sugammadex is available for rapid reversal of block. (See 'Sugammadex' below.) ○For endotracheal intubation for

Detailed dosage guidelines and administration information for Bridion (sugammadex). Includes dose adjustments, warnings and precautions.

Sugammadex Sugammadex is a modified cyclodextrin antidote used for rapid reversal of rocuronium and vecuronium Binds tightly to rocuronium in

Neither sugammadex nor the complex of sugammadex and rocuronium binds to plasma proteins or erythrocytes, as was shown in vitro using male human plasma and whole blood. Sugammadex exhibits linear kinetics in the dosage range of 1 to 16 mg/kg when administered as an IV bolus dose.