Bioavailability of DEPAKOTE ER Tablets Relative to DEPAKOTE When DEPAKOTE ER Dose is 8 to 20% Higher Study Regimens Relative Bioavailability Population DEPAKOTE ER vs. DEPAKOTE AUC24 Cmax Cmin Healthy Volunteers (N=35) 1000 1500 mg DEPAKOTE ER vs. 875 1250 mg DEPAKOTE 1.059 0.882 1.173 Patients with epilepsy on concomitant enzyme-inducing
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Bioavailability of DEPAKOTE ER Tablets Relative to DEPAKOTE When DEPAKOTE ER Dose is 8 to 20% Higher Study Regimens Relative Bioavailability Population DEPAKOTE ER vs. DEPAKOTE AUC24 Cmax Cmin Healthy Volunteers (N=35) 1000 1500 mg DEPAKOTE ER vs. 875 1250 mg DEPAKOTE 1.059 0.882 1.173 Patients with epilepsy on concomitant enzyme-inducing
Starting dosage migraines: 250 mg twice daily (the dose may be increased to 1500 mg daily in divided doses if needed). Depakote dosage for
1500 mg/day divalproex ER) and polytherapy on enzyme-inducing co-medications (induced, at 30 mg/day divalproex ER). divalproex sodium (Depakote
Table 1:Dose Conversion. Depakote (total daily dose in mg). Depakote SA (total daily dose in mg). . 750. . 1000. . 1250. . 1500.
DEPAKOTE ER relative to DEPAKOTE regimens (see following table). Bioavailability of DEPAKOTE ER Tablets Relative to DEPAKOTE When DEPAKOTE ER Dose is 8 to 20% Higher Study Regimens Relative Bioavailability Population DEPAKOTE ER vs. DEPAKOTE AUC24 Cmax Cmin Healthy Volunteers (N=35) 1000 1500 mg DEPAKOTE ER vs. 875 1250 mg DEPAKOTE 1.059 0.
He reported that a daily dose of 1500 mg of Depakote-ER often softened the arrival of his next cluster headache episode, as did prescribed
However, higher doses of Depakote are commonly used. In migraine prevention, doses of 750 to 1500 mg per day are optimal for many patients.
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