Height drugs for people with noonan syndrome

Noonan syndrome is also characterized by a slight increase in the risk for certain cancers. In a literature review spanning , Kratz et al found the most commonly reported cancers in Noonan syndrome, as diagnosed in a total of 1051 patients, to be neuroblastoma (8 cases), acute lymphoblastic leukemia (8 cases), low-grade glioma (6 cases), and rhabdomyosarcoma (6 cases); like Noonan

Noonan syndrome (NS) is a rare autosomal dominant condition or a genetic mutation present from birth, that causes a distinctive appearance and a range of health problems 91;1 93;. The most consistent features are wide-set eyes, low-set ears, short stature, and pulmonic stenosis. 91;2 93;People with Noonan syndrome may be mildly affected, or more severely affected. Noonan syndrome develops

It is a rare genetic disorder caused by a genetic mutation. It has many physical and developmental symptoms that usually start at birth. The condition has the tendency to appear in one of every 1000 to 2500 people and is more common in people with a family history of Noonan syndrome. What Causes Noonan Syndrome? Noonan syndrome is caused by a

Treatments for Noonan syndrome There's currently no single treatment for Noonan syndrome, but it's often possible to successfully manage many aspects of the

At birth, people with Noonan syndrome with multiple lentigines are typically of normal weight and height, but in some, growth slows over time. This slow growth results in affected individuals being shorter than average, although less than half of people with Noonan syndrome with multiple lentigines have significantly short stature.

The average age of the onset of puberty is delayed in people with Noonan syndrome compared with the general population: 35% of boys enter puberty after the age of 13 5 years; 44% of girls enter puberty after the age of 13 years. Fertility is not impaired in women with Noonan syndrome.

A 2024 study found that 25% of people with Noonan syndrome suffered from musculoskeletal pain, and 14% had joint stiffness in the wrists, elbows, ankles, knees and hips. A separate study, also in 2024, found that 62% of people with Noonan syndrome experienced chronic pain.

Other endocrinological features are confined to delayed puberty and hypogonadism in boys and males. To increase adult height, children with Noonan syndrome have been treated with human growth hormone since the 2024s. This seems to be beneficial in most of the children treated.

In other cases, medications are recommended. Heart monitoring by a cardiologist is a lifelong part of health care for many people with Noonan syndrome.