2.4 Dosage in Adult Patients With Renal Impairment. In adult patients with renal impairment (creatinine clearance 40 mL/min) and dialysis patients (hemodialysis and CAPD), the intravenous dose of ZOSYN should be reduced based on the degree of renal impairment.
Dosing during Continuous Renal Replacement Therapy. CVVH (Continuous Zosyn/Wyeth pharmaceuticals.
Renal Insufficiency In patients with renal insufficiency (Creatinine Clearance 40 mL/min), the intravenous dose of Zosyn (piperacillin and tazobactam for injection) should be adjusted to the degree of actual renal function impairment. In patients with nosocomial pneumonia receiving concomitant aminoglycoside therapy, the aminoglycoside
Dose Rounding Policy. Beta-Lactam Dosing. Beta-lactam dosing justification and education; Cefepime Dosing Protocol; Ceftolozane-tazobactam (Zerbaxa) dosing protocol; Piperacillin-tazobactam (Zosyn) dosing protocol; Renal Dose Adjustments. Renal Dosage Adjustment Protocol for Antimicrobials; Renal Dose Adjustment Guidance for Antimicrobial CRRT
Dose Rounding Policy. Beta-Lactam Dosing. Beta-lactam dosing justification and education; Cefepime Dosing Protocol; Ceftolozane-tazobactam (Zerbaxa) dosing protocol; Piperacillin-tazobactam (Zosyn) dosing protocol; Renal Dose Adjustments. Renal Dosage Adjustment Protocol for Antimicrobials; Renal Dose Adjustment Guidance for Antimicrobial CRRT
(Zosyn) - Drug Formulary Of the 84 total patients, data on appropriateness of dosing with respect to renal function were available on only 53 patients.
At creatinine clearance below 20 mL/min, the increase in half-life is twofold for piperacillin and fourfold for tazobactam compared to subjects with normal renal function. Dosage adjustments for ZOSYN are recommended when creatinine clearance is below 40 mL/min in patients receiving the usual recommended daily dose of ZOSYN.
Therefore, the use of piperacillin-tazobactam (Zosyn Proper dosing protocols were followed resulting in appropriate patient specific renal
Vancomycin plus piperacillin-tazobactam (aka vanc-zosyn or vosyn) is a popular broad-spectrum antibiotic regimen. renal tubule cells).
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