Overdose with diphenhydramine can cause symptoms ranging from CNS stimulation to CNS depression. The usual signs of mild overdose are sedation and clumsiness.
hydroxyzine. Increase monitoring of signs/symptoms of CNS depression in any patient receiving hydroxyzine together with another CNS depressant. Risk D
Mechanism of Action. The activity of metronidazole is specific for anaerobic bacteria and protozoa. 28 It is specific particularly for Giardia organisms. Metronidazole disrupts DNA in target microbes through reaction with intracellular metabolites. Clinical Signs. The most severe side effect of metronidazole is dose-related CNS toxicity.
E.g. aminoglycosides, fluoroquinolones, metronidazole. Use for toxoplasmosis controversial as may help clinical signs but not clear infection from CNS or eye.
If a patient is taking a gabapentinoid and a CNS depressant, e.g. opioids, closely monitor for signs of CNS depression, e.g. somnolence
HydrOXYzine: May enhance the CNS depressant effect of CNS Depressants. together with hydroxyzine. Increase monitoring of signs/symptoms of CNS
Getting back to metronidazole, if we inhibit GABA, then actions become more exaggerated. Signs of Metronidazole Toxicity. DOG: Signs of
hydroxyzine. Increase monitoring of signs/symptoms of CNS depression in any patient receiving hydroxyzine together with another CNS depressant. Risk D
Sign up. Conversation The best summation to date on metronidazole-related neurologic injury (both CNS
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SHOULD BE:
My forty year old body was starting to show signs of WEAR.
Tess (UK)